The Personalized Advantage Index: Translating Research on Prediction into Individualized Treatment Recommendations. A Demonstration
Identifieur interne : 000E71 ( Main/Exploration ); précédent : 000E70; suivant : 000E72The Personalized Advantage Index: Translating Research on Prediction into Individualized Treatment Recommendations. A Demonstration
Auteurs : Robert J. Derubeis [États-Unis] ; Zachary D. Cohen [États-Unis] ; Nicholas R. Forand [États-Unis] ; Jay C. Fournier [États-Unis] ; Lois A. Gelfand [États-Unis] ; Lorenzo Lorenzo-Luaces [États-Unis]Source :
- PLoS ONE [ 1932-6203 ] ; 2014.
Descripteurs français
- KwdFr :
- MESH :
- traitement médicamenteux : Trouble dépressif majeur.
- usage thérapeutique : Antidépresseurs.
- Directives de santé publique, Humains, Médecine individualisée, Pronostic, Recherche médicale translationnelle, Thérapie cognitive, Échelles d'évaluation en psychiatrie.
English descriptors
- KwdEn :
- MESH :
- chemical , therapeutic use : Antidepressive Agents.
- drug therapy : Depressive Disorder, Major.
- Cognitive Therapy, Health Planning Guidelines, Humans, Precision Medicine, Prognosis, Psychiatric Status Rating Scales, Translational Medical Research.
Abstract
Advances in personalized medicine require the identification of variables that predict differential response to treatments as well as the development and refinement of methods to transform predictive information into actionable recommendations.
To illustrate and test a new method for integrating predictive information to aid in treatment selection, using data from a randomized treatment comparison.
Data from a trial of antidepressant medications (N = 104) versus cognitive behavioral therapy (N = 50) for Major Depressive Disorder were used to produce predictions of post-treatment scores on the Hamilton Rating Scale for Depression (HRSD) in each of the two treatments for each of the 154 patients. The patient's own data were not used in the models that yielded these predictions. Five pre-randomization variables that predicted differential response (marital status, employment status, life events, comorbid personality disorder, and prior medication trials) were included in regression models, permitting the calculation of each patient's Personalized Advantage Index (PAI), in HRSD units.
For 60% of the sample a clinically meaningful advantage (PAI≥3) was predicted for one of the treatments, relative to the other. When these patients were divided into those randomly assigned to their “Optimal” treatment versus those assigned to their “Non-optimal” treatment, outcomes in the former group were superior (d = 0.58, 95% CI .17—1.01).
This approach to treatment selection, implemented in the context of two equally effective treatments, yielded effects that, if obtained prospectively, would rival those routinely observed in comparisons of active versus control treatments.
Url:
DOI: 10.1371/journal.pone.0083875
PubMed: 24416178
PubMed Central: 3885521
Affiliations:
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A Demonstration</title><author><name sortKey="Derubeis, Robert J" sort="Derubeis, Robert J" uniqKey="Derubeis R" first="Robert J." last="Derubeis">Robert J. Derubeis</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Department of Psychology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychology, University of Pennsylvania, Philadelphia, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Cohen, Zachary D" sort="Cohen, Zachary D" uniqKey="Cohen Z" first="Zachary D." last="Cohen">Zachary D. Cohen</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Department of Psychology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychology, University of Pennsylvania, Philadelphia, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Forand, Nicholas R" sort="Forand, Nicholas R" uniqKey="Forand N" first="Nicholas R." last="Forand">Nicholas R. 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Gelfand</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Department of Psychology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychology, University of Pennsylvania, Philadelphia, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Lorenzo Luaces, Lorenzo" sort="Lorenzo Luaces, Lorenzo" uniqKey="Lorenzo Luaces L" first="Lorenzo" last="Lorenzo-Luaces">Lorenzo Lorenzo-Luaces</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Department of Psychology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychology, University of Pennsylvania, Philadelphia, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antidepressive Agents (therapeutic use)</term><term>Cognitive Therapy</term><term>Depressive Disorder, Major (drug therapy)</term><term>Health Planning Guidelines</term><term>Humans</term><term>Precision Medicine</term><term>Prognosis</term><term>Psychiatric Status Rating Scales</term><term>Translational Medical Research</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Antidépresseurs (usage thérapeutique)</term><term>Directives de santé publique</term><term>Humains</term><term>Médecine individualisée</term><term>Pronostic</term><term>Recherche médicale translationnelle</term><term>Thérapie cognitive</term><term>Trouble dépressif majeur (traitement médicamenteux)</term><term>Échelles d'évaluation en psychiatrie</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antidepressive Agents</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Depressive Disorder, Major</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Trouble dépressif majeur</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antidépresseurs</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Cognitive Therapy</term><term>Health Planning Guidelines</term><term>Humans</term><term>Precision Medicine</term><term>Prognosis</term><term>Psychiatric Status Rating Scales</term><term>Translational Medical Research</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Directives de santé publique</term><term>Humains</term><term>Médecine individualisée</term><term>Pronostic</term><term>Recherche médicale translationnelle</term><term>Thérapie cognitive</term><term>Échelles d'évaluation en psychiatrie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Advances in personalized medicine require the identification of variables that predict differential response to treatments as well as the development and refinement of methods to transform predictive information into actionable recommendations.</p></sec><sec><title>Objective</title><p>To illustrate and test a new method for integrating predictive information to aid in treatment selection, using data from a randomized treatment comparison.</p></sec><sec><title>Method</title><p>Data from a trial of antidepressant medications (N = 104) versus cognitive behavioral therapy (N = 50) for Major Depressive Disorder were used to produce predictions of post-treatment scores on the Hamilton Rating Scale for Depression (HRSD) in each of the two treatments for each of the 154 patients. The patient's own data were not used in the models that yielded these predictions. Five pre-randomization variables that predicted differential response (marital status, employment status, life events, comorbid personality disorder, and prior medication trials) were included in regression models, permitting the calculation of each patient's Personalized Advantage Index (PAI), in HRSD units.</p></sec><sec><title>Results</title><p>For 60% of the sample a clinically meaningful advantage (PAI≥3) was predicted for one of the treatments, relative to the other. When these patients were divided into those randomly assigned to their “Optimal” treatment versus those assigned to their “Non-optimal” treatment, outcomes in the former group were superior (d = 0.58, 95% CI .17—1.01).</p></sec><sec><title>Conclusions</title><p>This approach to treatment selection, implemented in the context of two equally effective treatments, yielded effects that, if obtained prospectively, would rival those routinely observed in comparisons of active versus control treatments.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Hamburg, Ma" uniqKey="Hamburg M">MA Hamburg</name></author><author><name sortKey="Collins, Fs" uniqKey="Collins F">FS Collins</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Squassina, A" uniqKey="Squassina A">A Squassina</name></author><author><name sortKey="Manchia, M" uniqKey="Manchia M">M Manchia</name></author><author><name sortKey="Manolopoulos, Vg" uniqKey="Manolopoulos V">VG Manolopoulos</name></author><author><name sortKey="Artac, M" uniqKey="Artac M">M Artac</name></author><author><name sortKey="Lappa Manakou, C" uniqKey="Lappa Manakou C">C Lappa-Manakou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schosser, A" uniqKey="Schosser A">A Schosser</name></author><author><name sortKey="Kasper, S" uniqKey="Kasper S">S Kasper</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Simon, Ge" uniqKey="Simon G">GE Simon</name></author><author><name sortKey="Perlis, Rh" uniqKey="Perlis R">RH Perlis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mcclay, Jl" uniqKey="Mcclay J">JL McClay</name></author><author><name sortKey="Adkins, De" uniqKey="Adkins D">DE Adkins</name></author><author><name sortKey=" Berg, K" uniqKey=" Berg K">K Åberg</name></author><author><name sortKey="Stroup, S" uniqKey="Stroup S">S Stroup</name></author><author><name sortKey="Perkins, Do" uniqKey="Perkins D">DO Perkins</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Malhotra, Ak" uniqKey="Malhotra A">AK Malhotra</name></author><author><name sortKey="Zhang, J P" uniqKey="Zhang J">J-P Zhang</name></author><author><name sortKey="Lencz, T" uniqKey="Lencz T">T Lencz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guo, Y" uniqKey="Guo Y">Y Guo</name></author><author><name sortKey="Dubois Bowman, F" uniqKey="Dubois Bowman F">F DuBois Bowman</name></author><author><name sortKey="Kilts, C" uniqKey="Kilts C">C Kilts</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gong, Q" uniqKey="Gong Q">Q Gong</name></author><author><name sortKey="Wu, Q" uniqKey="Wu Q">Q Wu</name></author><author><name sortKey="Scarpazza, C" uniqKey="Scarpazza C">C Scarpazza</name></author><author><name sortKey="Lui, S" uniqKey="Lui S">S Lui</name></author><author><name sortKey="Jia, Z" uniqKey="Jia Z">Z Jia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baskaran, A" uniqKey="Baskaran A">A Baskaran</name></author><author><name sortKey="Milev, R" uniqKey="Milev R">R Milev</name></author><author><name sortKey="Mcintyre, Rs" uniqKey="Mcintyre R">RS McIntyre</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Leykin, Y" uniqKey="Leykin Y">Y Leykin</name></author><author><name sortKey="Amsterdam, Jd" uniqKey="Amsterdam J">JD Amsterdam</name></author><author><name sortKey="Derubeis, Rj" uniqKey="Derubeis R">RJ DeRubeis</name></author><author><name sortKey="Gallop, R" uniqKey="Gallop R">R Gallop</name></author><author><name sortKey="Shelton, Rc" uniqKey="Shelton R">RC Shelton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fournier, Jc" uniqKey="Fournier J">JC Fournier</name></author><author><name sortKey="Derubeis, Rj" uniqKey="Derubeis R">RJ DeRubeis</name></author><author><name sortKey="Shelton, Rc" uniqKey="Shelton R">RC Shelton</name></author><author><name sortKey="Gallop, R" uniqKey="Gallop R">R Gallop</name></author><author><name sortKey="Amsterdam, Jd" uniqKey="Amsterdam J">JD Amsterdam</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fournier, Jc" uniqKey="Fournier J">JC Fournier</name></author><author><name sortKey="Derubeis, Rj" uniqKey="Derubeis R">RJ DeRubeis</name></author><author><name sortKey="Shelton, Rc" uniqKey="Shelton R">RC Shelton</name></author><author><name sortKey="Hollon, Sd" uniqKey="Hollon S">SD Hollon</name></author><author><name sortKey="Amsterdam, Jd" uniqKey="Amsterdam J">JD Amsterdam</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jarrett, Rb" uniqKey="Jarrett R">RB Jarrett</name></author><author><name sortKey="Schaffer, M" uniqKey="Schaffer M">M Schaffer</name></author><author><name sortKey="Mcintire, D" uniqKey="Mcintire D">D McIntire</name></author><author><name sortKey="Witt Browder, A" uniqKey="Witt Browder A">A Witt-Browder</name></author><author><name sortKey="Kraft, D" uniqKey="Kraft D">D Kraft</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dawes, Rm" uniqKey="Dawes R">RM Dawes</name></author><author><name sortKey="Faust, D" uniqKey="Faust D">D Faust</name></author><author><name sortKey="Meehl, Pe" uniqKey="Meehl P">PE Meehl</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barber, Jp" uniqKey="Barber J">JP Barber</name></author><author><name sortKey="Muenz, Lr" uniqKey="Muenz L">LR Muenz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Derubeis, Rj" uniqKey="Derubeis R">RJ DeRubeis</name></author><author><name sortKey="Hollon, Sd" uniqKey="Hollon S">SD Hollon</name></author><author><name sortKey="Amsterdam, Jd" uniqKey="Amsterdam J">JD Amsterdam</name></author><author><name sortKey="Shelton, Rc" uniqKey="Shelton R">RC Shelton</name></author><author><name sortKey="Young, Pr" uniqKey="Young P">PR Young</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hollon, Sd" uniqKey="Hollon S">SD Hollon</name></author><author><name sortKey="Derubeis, Rj" uniqKey="Derubeis R">RJ DeRubeis</name></author><author><name sortKey="Shelton, Rc" uniqKey="Shelton R">RC Shelton</name></author><author><name sortKey="Amsterdam, Jd" uniqKey="Amsterdam J">JD Amsterdam</name></author><author><name sortKey="Salomon, Rmr" uniqKey="Salomon R">RMR Salomon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hamilton, M" uniqKey="Hamilton M">M Hamilton</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Kirsch, I" uniqKey="Kirsch I">I Kirsch</name></author><author><name sortKey="Deacon, Bj" uniqKey="Deacon B">BJ Deacon</name></author><author><name sortKey="Huedo Medina, Tb" uniqKey="Huedo Medina T">TB Huedo-Medina</name></author><author><name sortKey="Scoboria, A" uniqKey="Scoboria A">A Scoboria</name></author><author><name sortKey="Moore, Tj" uniqKey="Moore T">TJ Moore</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Kraemer, H" uniqKey="Kraemer H">H Kraemer</name></author><author><name sortKey="Blasey, C" uniqKey="Blasey C">C Blasey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Efron, B" uniqKey="Efron B">B Efron</name></author><author><name sortKey="Gong, G" uniqKey="Gong G">G Gong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Harrell, Fe" uniqKey="Harrell F">FE Harrell</name></author><author><name sortKey="Lee, Kl" uniqKey="Lee K">KL Lee</name></author><author><name sortKey="Mark, Db" uniqKey="Mark D">DB Mark</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Turner, Eh" uniqKey="Turner E">EH Turner</name></author><author><name sortKey="Matthews, Am" uniqKey="Matthews A">AM Matthews</name></author><author><name sortKey="Linardatos, E" uniqKey="Linardatos E">E Linardatos</name></author><author><name sortKey="Tell, Ra" uniqKey="Tell R">RA Tell</name></author><author><name sortKey="Rosenthal, R" uniqKey="Rosenthal R">R Rosenthal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Leucht, S" uniqKey="Leucht S">S Leucht</name></author><author><name sortKey="Hierl, S" uniqKey="Hierl S">S Hierl</name></author><author><name sortKey="Kissling, W" uniqKey="Kissling W">W Kissling</name></author><author><name sortKey="Dold, M" uniqKey="Dold M">M Dold</name></author><author><name sortKey="Davis, Jm" uniqKey="Davis J">JM Davis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Derubeis, Rj" uniqKey="Derubeis R">RJ DeRubeis</name></author><author><name sortKey="Siegle, Gj" uniqKey="Siegle G">GJ Siegle</name></author><author><name sortKey="Hollon, Sd" uniqKey="Hollon S">SD Hollon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Uhr, M" uniqKey="Uhr M">M Uhr</name></author><author><name sortKey="Tontsch, A" uniqKey="Tontsch A">A Tontsch</name></author><author><name sortKey="Namendorf, C" uniqKey="Namendorf C">C Namendorf</name></author><author><name sortKey="Ripke, S" uniqKey="Ripke S">S Ripke</name></author><author><name sortKey="Lucae, S" uniqKey="Lucae S">S Lucae</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Ising, M" uniqKey="Ising M">M Ising</name></author><author><name sortKey="Lucae, S" uniqKey="Lucae S">S Lucae</name></author><author><name sortKey="Binder, Eb" uniqKey="Binder E">EB Binder</name></author><author><name sortKey="Bettecken, T" uniqKey="Bettecken T">T Bettecken</name></author><author><name sortKey="Uhr, M" uniqKey="Uhr M">M Uhr</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Arranz, Mj" uniqKey="Arranz M">MJ Arranz</name></author><author><name sortKey="Kapur, S" uniqKey="Kapur S">S Kapur</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Perlis, Rh" uniqKey="Perlis R">RH Perlis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Uher, R" uniqKey="Uher R">R Uher</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Kraemer, Hc" uniqKey="Kraemer H">HC Kraemer</name></author><author><name sortKey="Wilson, Gt" uniqKey="Wilson G">GT Wilson</name></author><author><name sortKey="Fairburn, Cg" uniqKey="Fairburn C">CG Fairburn</name></author><author><name sortKey="Agras, Ws" uniqKey="Agras W">WS Agras</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kraemer, Hc" uniqKey="Kraemer H">HC Kraemer</name></author><author><name sortKey="Frank, E" uniqKey="Frank E">E Frank</name></author><author><name sortKey="Kupfer, Dj" uniqKey="Kupfer D">DJ Kupfer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Byar, Dp" uniqKey="Byar D">DP Byar</name></author><author><name sortKey="Corle, Dk" uniqKey="Corle D">DK Corle</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Byar, Dp" uniqKey="Byar D">DP Byar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yakovlev, A" uniqKey="Yakovlev A">A Yakovlev</name></author><author><name sortKey="Goot, Re" uniqKey="Goot R">RE Goot</name></author><author><name sortKey="Osipova, Tt" uniqKey="Osipova T">TT Osipova</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Ohio</li><li>Pennsylvanie</li></region><settlement><li>Pittsburgh</li></settlement><orgName><li>Université de Pittsburgh</li></orgName></list><tree><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Derubeis, Robert J" sort="Derubeis, Robert J" uniqKey="Derubeis R" first="Robert J." last="Derubeis">Robert J. Derubeis</name></region><name sortKey="Cohen, Zachary D" sort="Cohen, Zachary D" uniqKey="Cohen Z" first="Zachary D." last="Cohen">Zachary D. Cohen</name><name sortKey="Forand, Nicholas R" sort="Forand, Nicholas R" uniqKey="Forand N" first="Nicholas R." last="Forand">Nicholas R. Forand</name><name sortKey="Fournier, Jay C" sort="Fournier, Jay C" uniqKey="Fournier J" first="Jay C." last="Fournier">Jay C. Fournier</name><name sortKey="Gelfand, Lois A" sort="Gelfand, Lois A" uniqKey="Gelfand L" first="Lois A." last="Gelfand">Lois A. Gelfand</name><name sortKey="Lorenzo Luaces, Lorenzo" sort="Lorenzo Luaces, Lorenzo" uniqKey="Lorenzo Luaces L" first="Lorenzo" last="Lorenzo-Luaces">Lorenzo Lorenzo-Luaces</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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